Mega roles of microRNAs in regulation of skeletal muscle health and disease
نویسندگان
چکیده
Skeletal muscle is a dynamic tissue with remarkable plasticity. Skeletal muscle growth and regeneration are highly organized processes thus it is not surprising that a high degree of complexity exists in the regulation of these processes. Recent discovery of non-coding microRNAs (miRNAs) has prompted extensive research in understanding the roles of these molecules in skeletal muscle. Research so far shows that miRNAs play a very significant role at every aspect of muscle biology. Besides muscle growth, development, and regeneration miRNAs are also involved in the pathology of muscle diseases and metabolism. In this review, recent advancements in miRNA function during myogenesis, exercise, atrophy, aging, and dystrophy are discussed.
منابع مشابه
Comparison of the Effectiveness of Emotion Regulation Method Based on Gross Model and Muscle Relaxation Technique on Perceived Stress, Anxiety, and Resilience in Patients with Coronary Heart Disease
Introduction: This study aimed to compare the effectiveness of the emotion regulation method based on the Gross model and muscle relaxation technique on perceived stress, anxiety, and resilience in patients with coronary heart disease (CHD). Material & Methods: This study quasi-experimental study had a pretest-posttest design and follow-up and control groups. The statistical population included...
متن کاملMicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: potential drug targets?
The identification of non-coding RNA species, previously thought of as 'junk' DNA, adds a new dimension of complexity to the regulation of DNA, RNA and protein. MicroRNAs are short non-coding RNA species that control gene expression, are dysregulated in settings of cardiac and skeletal muscle disease and have emerged as promising therapeutic targets. MicroRNAs specifically enriched in cardiac a...
متن کاملExtracellular vesicle microRNAs mediate skeletal muscle myogenesis and disease
Skeletal muscle function is important for good health and independent living, and has been subject to numerous studies focused on skeletal muscle development, function and metabolism. However, progressive and degenerative changes in skeletal muscle function often occur following physiological and pathological stress, and these lead to the progression of diabetes, obesity, chronic kidney disease...
متن کاملMicroRNAs in skeletal muscle: their role and regulation in development, disease and function
Maintaining skeletal muscle function throughout the lifespan is a prerequisite for good health and independent living. For skeletal muscle to consistently function at optimal levels, the efficient activation of processes that regulate muscle development, growth, regeneration and metabolism is required. Numerous conditions including neuromuscular disorders, physical inactivity, chronic disease a...
متن کاملThe effect of high-intensity interval training (HIIT) on gene expression of apoptotic markers in the skeletal muscle of diabetic rats
Background and Aims: Apoptosis plays important roles in the pathophysiology of Type 2 diabetes. The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) on gene expression of apoptotic markers in the skeletal muscle of diabetic rats. Methods: To implementation of this experimental research, 60 male Wistar rats weighing 220 ± 20 gr randomly were divided into 5 ...
متن کامل